Anxiety, stress, and worry
Wired, tired, and stuck. Negative thought loops.
See if treatment is right for meAt-home ketamine treatment
Feel more like yourself again.
- Personalized, provider-directed daily protocol
- No in-person visits — meet your clinician by video
- From $129/mo, medication delivered to your door
Ketamine is FDA approved but prescribed off-label for anxiety and depression.
Treatment for your specific situation
Low mood, no joy, no motivation
Depression — with or without chronic pain.
See if treatment is right for meAntidepressants left me flat / didn’t help
SSRI side effects: low libido, feeling emotionally blunt.
See if treatment is right for mePanic attacks, severe anxiety, or PTSD
Sudden waves of fear. A body on high alert.
See if treatment is right for me65% of Joyous patients name positivity and joy as a treatment goal — and 89% report relief within the first month.
The treatment
A better approach to mental health treatment
What it is
Sub-dissociative, taken at home
A low daily dose of ketamine, prescribed off-label by a licensed clinician. Your daily dose is tailored to you and is much lower than a typical in-clinic dose — designed to fit into your day.
A buccal troche, it dissolves against the inside of your cheek.
choose your flavor.
The science
What research shows about ketamine
Unlike traditional antidepressants that target serotonin, ketamine works through a different pathway — boosting glutamate signaling to trigger neuroplasticity, your brain's natural ability to form new neural connections and repair pathways damaged by chronic stress.
How it feels
Subtle, not overwhelming
What patients report in their check-ins:
Joyous patient check-in data; "ever selected" across a patient's check-in history.
Joyous outcomes data
Many patients notice a change in the first week or two — but benefits compound.
86%
cut their depression score in half or better
PHQ-9 · six weeks · n = 43,56387%
cut their anxiety score in half or better
GAD-7 · six weeks · n = 41,51016 days
typical time to cut a depression score in half
median · 48 days to the remission rangeJoyous outcomes data among patients starting at PHQ-9 ≥ 10 for depression or GAD-7 ≥ 10 for anxiety, who remained in treatment. Self-reported scores; no control group. Individual results vary. Antidepressants are generally described as taking 4–8 weeks.
How treatment works through Joyous
5 minutesOnline assessmentA few quick questions to see if Joyous is right for you.
Video visitMeet your clinicianA licensed provider will assess your history and goals and prescribe personalized treatment, if appropriate.
To your doorFree, discreet deliveryMedication ships discreetly to your door.- OngoingDose discovery and supportYour dose is found, not guessed — start low, check in daily, your clinician adjusts it until it's right.
Feel supported in your healing process
Ease into treatment
Your clinician starts you low and helps you find the dose that fits — your dose is found, not guessed.
Get guidance as treatment progresses
AI-powered daily check-ins help you and your clinician track how you're feeling over time. Support materials designed by psychotherapists and providers specifically for this medication help you process emotions and make lasting changes.
Stay in touch with your clinician
Provider-led care doesn't end at the prescription — your clinician follows your progress and is available on demand.
Adjust treatment if needed
Your clinician will adjust your dose as needed, based on how you're doing.
Convenient and affordable treatment
What’s included
- Check-in appointments with a licensed provider
- Monthly supply of medication, shipped for free
- Personalized dose and treatment plan
- Guides and courses
$129/mo with a 3-month commitment
Or $159/mo month to month — drops to $129/mo after 3 months
Get startedHSA/FSA eligible
Trustpilot4.6 · 1,900+Google4.6 · 900+
+100,000 patients treated.
“It’s the fact that I can function on such a small amount of medication instead of having to take 5–6 different things at once to manage my mental health. […] Now I take my Joyous, and it keeps me stable, productive, and full of joy! People notice the difference at work, at home, and at church. The impact it’s had on me is genuinely noticeable, and in such a positive way.”
“Before joyous, my panic attacks controlled me. Multiple times a day […] Now, I’m able to pull myself out of the panic attacks a lot quicker. I recommend this to EVERYONE struggling with depression and anxiety.”
“Joyous gave me my life back after I felt hope was gone. The medicine worked so quickly and so well, it’s changed my life. I’ve been taking psychiatric medication for most of my life, and none of them have come close to what ketamine has given me. No more panic attacks, anxiety is extremely low as is depression. My mind isn’t constantly running negative thoughts and memories.”
“I had used SSRIs in the past which fell flat and made me feel worse. Ketamine therapy helped me actually get to the root of problems, recall painful experiences with grace, and manage moderate-severe depression.”
LegitScript CertifiedVerified Healthcare ProviderA note from our clinical team
Mental healthcare shouldn’t require you to put your life on pause. We built a daily, provider-directed protocol that is highly efficacious and fits into real routines — meeting you where you are, at home.
Frequently asked questions
Who is a fit for ketamine therapy?
Joyous offers provider-directed, at-home ketamine treatment prescribed off-label for depression and anxiety. Many patients also come with chronic stress and burnout, high-functioning anxiety or depression, grief, trauma, or chronic pain. A licensed clinician reviews your diagnosis, medical history, and goals to decide whether treatment is appropriate for you.
Who is NOT a fit for ketamine therapy?
Ketamine treatment may not be appropriate for people with psychosis or bipolar I, active suicidal intent, uncontrolled high blood pressure, a seizure history, a history of stroke or brain injury, pregnancy or breastfeeding, or active or recent substance use disorder. Joyous screens for these conditions before prescribing; your clinician makes the final decision. Joyous is not for emergencies. If you are in crisis, call or text 988; for an immediate emergency, call 911.
What does low-dose ketamine feel like?
Our low-dose protocol is designed to keep you present and coherent during treatment, but effects vary. After about 15 minutes you may notice a subtle calm, and some patients experience lightheadedness or feel a little “out of it” for 30 to 40 minutes. We recommend taking a moment for meditation or reflection. Over the first weeks, your clinician adjusts your dose using your daily check-ins. If the feeling isn’t right, tell your clinician; they may recommend adjusting or splitting your dose. Do not drive after a dose; follow your clinician’s instructions about when to resume driving.
How fast does ketamine therapy work?
Antidepressants are generally described as taking four to eight weeks to work. In Joyous outcomes data, among patients starting with moderate or worse depression (PHQ-9 ≥ 10) who remained in treatment, the average depression score had dropped 38% by the end of week one. The typical patient’s score was cut in half within about 16 days. That is a median among people who responded and stayed in treatment; half took longer, and reaching the PHQ-9 remission range (a score under 5) took a median of 48 days. These are self-reported scores, with no control group; individual results vary.
Does it work for anxiety and depression?
In Joyous outcomes data, 86% of patients who started with moderate or worse depression (PHQ-9 ≥ 10) cut their score in half or better within six weeks, and 54% reached the PHQ-9 remission range (a score under 5). Among patients starting with moderate or worse anxiety (GAD-7 ≥ 10), 87% cut their score in half or better within six weeks, and 59% reached the GAD-7 remission range (a score under 5). Measured among patients who stayed in treatment, using self-reported scores; no control group; individual results vary.
Is at-home ketamine safe?
At-home ketamine treatment rests on three things: a low daily dose designed to be sub-dissociative, screening by a licensed clinician before you start, and daily check-ins so your dose changes only when your clinician approves them. Treatment carries risks, and side effects can occur. Drowsiness was the most common side effect in Joyous outcomes data: about 1 in 4 patients in week one, fewer than 1 in 5 by week six. Your clinician will review risks and precautions with you. Do not drive after a dose; follow your clinician’s instructions about when to resume driving.
Can I keep taking other medications?
Many patients continue their existing antidepressant during treatment. Ketamine works through a different mechanism than SSRIs, typically much faster. It has its own potential side effects and interactions. Tell your clinician about everything you take; they will talk through whether treatment fits alongside your current medications. Never stop or change a medication without talking to your prescriber.
Is it safe to take before a therapy session?
Some patients pair their dose with a therapy session, as directed by their provider. Ask your clinician whether this is appropriate for you and how to time your dose; effects vary, and you may feel drowsy or lightheaded. For a video session, stay home afterward. Do not drive after a dose; follow your clinician’s instructions about when to resume driving. If therapy is in person, arrange for someone else to drive you.
Is it covered by insurance?
Insurance does not cover Joyous treatment. HSA and FSA funds are accepted.
Treatment for real life. Be Joyous.
Get startedKetamine is FDA approved but prescribed off-label for anxiety and depression. Side effects can occur; your clinician will review risks with you. Joyous is not for emergencies.