Ketamine has been a game changer
I have struggled with anxiety my whole life. Tried many unhealthy and prescribed remedies. None worked. Ketamine has been a game changer. I would highly recommend this to anyone...
Will
Low-dose ketamine · 120,000+ patients treated
Anxiety, treated at home
Wired, tired and stuck in the same thought loops? Low-dose ketamine, prescribed by licensed clinicians and adjusted to you with daily check-ins.
See if treatment is right for me- Free consultation · no credit card needed
- HSA/FSA accepted
“It is so easy to let the little things go that I would normally obsess on.
Now my days are full of happiness and excitement.”
Monika, Joyous patient
The neuroscience
Not another serotonin treatment.
A different system.
Tap to compare ↑
Ketamine modulates glutamate, which can help the brain form new connections and break old anxiety thought loops. That's called neuroplasticity.
Most traditional anxiety treatments target serotonin. Antidepressants are generally described as taking 4 to 8 weeks to work.
- Stuck
- Signal
- Rebuild
Moda-Sava et al., Science 2019 · Li et al., Science 2010 · Wang, Kavalali & Monteggia, Cell 2022
Four ways to take ketamine. Only one keeps you coherent and aware.
- Joyous low daily doseHome, your routine✓ Coherent and aware
- IV infusionClinic✕ Not coherent or aware
- Spravato sprayClinic✕ Not coherent or aware
- High-dose sessionsHome, with a sitter✕ Not coherent or aware
Source: joyous.team/ketamine-therapy. Ketamine for mental health is prescribed off-label.
Licensed clinicians + daily check-ins + 32 states
Low dose. Subtle by design.
Small enough to take at home every day, with no trip and no downtime.
Dose
5-20×lower than standard clinical doses
Feeling
78%
felt relaxed in their body during treatment
Daily check-ins · 30,355 patients
You stay coherent and aware. Not a trip.
Getting started takes minutes
- Online assessmentAnswer a few questions, see if you qualify.
- Meet your clinicianA licensed clinician assesses your symptoms and prescribes your protocol, by video.
- Free shipmentMedication ships discreetly to your door.
See if I qualify
Free consultation · no credit card needed
I have struggled with anxiety my whole life. Tried many unhealthy and prescribed remedies. None worked. Ketamine has been a game changer.
W
WillJoyous patient, US
Your dose is found, not guessed.
Treatment starts low and rises in small steps only as tolerated, until your clinician finds your lowest effective dose. There is no standard dose: yours is set from your own daily check-ins, and every dose change is approved by a licensed clinician.
Start on a low doseCheck in dailyYour optimal dose is found & adjusted over time
Anxiety is a loop.
Here’s what six weeks looked like.
Joyous patients who started with moderate or worse anxiety.
“My anxiety over small things is nearly nonexistent.” Jade Echo, Joyous patient
87%
cut their anxiety score in half or better (GAD-7, six weeks, n = 41,510)
59%
reached the remission range for anxiety (GAD-7 under 5, six weeks)
Not easy cases. Most Joyous patients had lived with their symptoms for over two years, and about 29% had tried three or more antidepressants.
* Joyous outcomes data · moderate-or-worse anxiety at start · self-reported GAD-7 · individual results vary
Study detailsPatients who started with moderate or worse anxiety (GAD-7 of 10 or higher) and remained in treatment, self-reported GAD-7 scores at six weeks. Remission range means a GAD-7 score under 5. No control group. Individual results vary.
Why people choose Joyous
Come for joy.
Most people don’t come to feel less bad. They come to feel good.
Calm you can feel from the first dose
Patients with anxiety report a sense of calm and mental spaciousness after taking their dose, often within about 15 minutes. Many notice a change in the first week or two, and the benefits compound.
Anxiety score, GAD-7 (lower is better). Illustration of milestones, not a measured curve.
↻ ReplayQuestions people actually ask
Got a question we didn’t cover? Email [email protected] or text +1 (844) 774-0909.
Does ketamine work for anxiety?
In Joyous outcomes data, among patients starting with moderate or worse anxiety (GAD-7 of 10 or more), 87% cut their score in half or better within six weeks, and 59% reached the GAD-7 remission range (a score under 5). Measured among patients who stayed in treatment, using self-reported scores; no control group; individual results vary.
Does ketamine therapy get you high?
No. The Joyous dose is designed not to: you stay coherent and aware throughout. Most people describe it as calming rather than intoxicating.
Is at home ketamine safe?
At-home ketamine treatment rests on three things: a low daily dose designed not to produce a high, screening by a licensed clinician before you start, and daily check-ins so the dose only moves when your clinician approves it. You stay coherent and aware throughout; the most common side effect in Joyous outcomes data was drowsiness (about 1 in 4 patients in week one, fewer than 1 in 5 by week six). Do not drive for 1 to 2 hours after a dose.
Who is ketamine therapy not right for?
Psychosis or bipolar I, active suicidal intent, uncontrolled high blood pressure, seizure history, a history of stroke or brain injury, pregnancy or breastfeeding, active or past substance use disorder. A licensed clinician screens out patients with any of these.
Can I keep taking other medications?
Many patients continue their existing medication during treatment. Your clinician reviews your current medications at your video assessment and decides what is compatible. Bring your medication list.
How is this different from Spravato or IV ketamine?
Spravato is esketamine, a nasal spray FDA-approved for treatment-resistant depression, taken under observation at a certified clinic. Clinic infusions are higher doses, also given under observation. Joyous prescribes racemic ketamine off-label as a low daily dose you take at home, adjusted from your own check-ins. The point of the low dose is that no one needs to sit with you while you take it, paired with proper mental-health follow-up.
How fast does ketamine therapy work?
Patients with anxiety report a sense of calm and mental spaciousness after taking the medication; after about 15 minutes you may notice a subtle calm. Many patients notice a change in the first week or two, and benefits compound: among patients starting with moderate or worse anxiety, 87% cut their GAD-7 score in half or better within six weeks. Self-reported scores; individual results vary.
What does low-dose ketamine feel like?
Our low-dose protocol is designed to keep you fully present and coherent during treatment. After about 15 minutes you may notice a subtle calm and possibly some lightheadedness that quickly dissipates. Over the first weeks your dose is adjusted from your daily check-ins, so if the feeling isn’t right it will get adjusted.
Is ketamine legal?
Yes. Ketamine is a federally controlled prescription medication: legal when prescribed by a licensed clinician, and prescribed off-label for depression, anxiety and PTSD. Joyous clinicians prescribe it in 32 states.
Do I need to be in therapy to do this?
No, but many people are. 38% of Joyous patients were in talk therapy at the same time, rising to 44% among those with moderate or worse symptoms. If therapy is out of reach, the Joyous patient app includes curated treatment courses and resources you can work through on your own.
How much does ketamine therapy cost?
Joyous costs $129 a month on the plan with a three-month commitment, or $159 a month with no commitment, which drops to $129 after three months. Both include the medication.
Does insurance cover ketamine therapy?
Insurance does not cover Joyous. HSA and FSA funds are accepted.
How it works
Treatment starts low and rises in small steps only as tolerated, until your clinician finds your lowest effective dose. You check in daily, and the dose only moves when your clinician approves it.
Who it’s for
Most patients come for depression, anxiety and PTSD; many also with chronic stress and burnout, high-functioning anxiety or depression, grief and trauma, OCD, and chronic pain. Most had lived with their symptoms for over two years. About 17% had never taken an antidepressant; about 29% had tried three or more.
Who is screened out
Psychosis or bipolar I, active suicidal intent, uncontrolled high blood pressure, seizure history, a history of stroke or brain injury, pregnancy or breastfeeding, active or past substance use disorder. A licensed clinician screens out patients with any of these.
Join 120,000+ patients treated by Joyous
Talk to a clinician first.
Pay nothing today.
- 1
Free video consultation Free
Meet the Joyous medical team. No credit card, no commitment. - 2Decide togetherA licensed provider goes over your history and questions, and you decide together if ketamine is right for you.
- 3Only then, pick a planIf it is, choose a plan and pay for your first month. Cancel anytime.
Your free consultation$0
- ✓Video visit with the Joyous medical team
- ✓Your medical history and questions reviewed
- ✓No credit card needed
- ✓No commitment
No credit card needed. If it’s not right for you, you just walk away.
If you’re approved: pick a plan
Best price
3-month plan
$129/mo
with a 3-month commitment
No commitment
Month to month
$159/mo
then $129/mo after 3 months
Every plan includes
- Medication & shipping
- Provider appointments
- Be Joyous™ patient platform
- Joyous Care support
- Mental health resources
- Access to our patient community
HSA/FSA accepted · Not covered by insurance
S
“Least expensive option for low dose oral ketamine. Everything is done online over zoom and its very easy.”
Stephen C., Trustpilot
Led by clinicians
Directed by licensed clinicians, the Joyous protocol is continuously adapted to each patient via a system of daily check-ins.
Medically reviewed by Bobbi Leben, MD.
Bobbi Leben, MD
Chief Medical Officer, Joyous. Double board certified.
There is no health without mental health.
The Joyous team
A Public Benefit Corporation
Most people don’t come to feel less bad. They come to feel good.
Come for joy.
65% of patients come for positivity and joy (n = 28,013)
66,727 patients in Joyous outcomes data
Come for joy
120,000+ patients treated
4.7 on Trustpilot
LegitScript certifiedPublic Benefit Corporation
Available in 32 states
HSA/FSA accepted
★ 4.7 on Trustpilot · 2,246 reviews
Real people, real words
My anxiety is almost completely gone
My journey was great. I took it for 5 months. Now my anxiety is almost completely gone. Also my depression went away. I feel a whole lot better than I have in ten years
Brandon G
The best treatment for depression and anxiety!
I started to feel major improvements in my depression within a couple of weeks. After about 2 months, I felt a tremendous relief in my anxiety symptoms!
Anjanette
My panic attacks controlled me
Before joyous, my panic attacks controlled me. Multiple times a day […] Now, I’m able to pull myself out of the panic attacks a lot quicker. I recommend this to EVERYONE struggling with depression and anxiety.
Lynn H.
Joyous gave my life back
The medicine worked so quickly and so well, it’s changed my life. No more panic attacks, anxiety is extremely low as is depression. My mind isn’t constantly running negative thoughts and memories.
Leslie W. B.
Grateful for Joyous helped me through Depression and Anxiety
Ketamine has been a different experience no side effects, and a noticeable lift in my mood and clarity. It also helped me manage anxiety during some very challenging college courses.
Shelly V.
One of the best decisions I’ve ever made
I’ve been on SSRIs, SNRIs & benzodiazapines since childhood. Nothing has ever worked without awful side effects. Joyous has been like magic for my brain. I’m actually making progress in therapy!
Amber M.
This treatment has saved my life
I don’t feel like a cloud is constantly over me, my ADHD has greatly improved, and my anxiety over small things is nearly nonexistent.
Jade Echo
Productive, Stable and Happy!
It’s the fact that I can function on such a small amount of medication instead of having to take 5–6 different things at once to manage my mental health. […] Now I take my Joyous, and it keeps me stable, productive, and full of joy!
Snookes
Start with a free consultation
Free consultation · no credit card needed
Four kinds of ketamine therapy
Ketamine therapy comes in four main forms. Here is how they differ.
IV infusion
Spravato
Higher-dose at home
Taken at home
You stay coherent and aware
No one needs to sit with you
Sitter often required
Dosing
Small daily dose
Series of sessions
With an oral antidepressant
Set weekly sessions
Adjusted from daily check-ins
FDA status for mental health
Off-label
Off-label
FDA-approved
Off-label
Source: joyous.team/ketamine-therapy, “What kinds of ketamine therapy are there?”
Explore my options
Free consultation · no credit card needed
About Joyous
To enable individuals, families, communities, and humanity to live a Joyous life.
Joyous is a Public Benefit Corporation that puts patients’ well-being as our #1 priority, born out of a collaboration among medical experts, psychology specialists, and Silicon Valley technologists.
Conditions we treat
Joyous clinicians can prescribe ketamine for any psychiatric diagnosis where they judge it appropriate.
Most commonAnxietyLearn more
Most commonDepressionLearn more
Most commonPTSDLearn more
Chronic stressLearn more
Performance anxietyLearn more
GriefLearn more
OCDLearn more
SleepLearn more
Joyous at-home ketamineFree consultation · no card needed
Get Started