Quite literally life saving
Having been living with depression for 22 years, I never knew life could be this … well, joyous!! I feel like I have superpowers.
Eva D
Low-dose ketamine · 120,000+ patients treated
Depression, treated at home
When depression has taken over your days. Low-dose ketamine, prescribed by licensed clinicians and adjusted to you with daily check-ins.
See if treatment is right for me- Free consultation · no credit card needed
- HSA/FSA accepted
“I started to feel major improvements in my depression
within a couple of weeks.”
Anjanette, Joyous patient
The neuroscience
Not another antidepressant.
A different system.
Tap to compare ↑
Ketamine boosts glutamate signaling, which can help the brain form new connections. That's called neuroplasticity.
Most antidepressants target serotonin. They're generally described as taking 4 to 8 weeks to work.
- Stuck
- Signal
- Rebuild
Moda-Sava et al., Science 2019 · Li et al., Science 2010 · Wang, Kavalali & Monteggia, Cell 2022
Four ways to take ketamine. Only one keeps you coherent and aware.
- Joyous low daily doseHome, your routine✓ Coherent and aware
- IV infusionClinic✕ Not coherent or aware
- Spravato sprayClinic✕ Not coherent or aware
- High-dose sessionsHome, with a sitter✕ Not coherent or aware
Source: joyous.team/ketamine-therapy. Ketamine for mental health is prescribed off-label.
Licensed clinicians + daily check-ins + 32 states
Low dose. Subtle by design.
Small enough to take at home every day, with no trip and no downtime.
Dose
5-20×lower than standard clinical doses
Feeling
56%
felt an openness that helped them explore their feelings
Daily check-ins · 30,355 patients
You stay coherent and aware. Not a trip.
Getting started takes minutes
- Online assessmentAnswer a few questions, see if you qualify.
- Meet your clinicianA licensed clinician assesses your symptoms and prescribes your protocol, by video.
- Free shipmentMedication ships discreetly to your door.
See if I qualify
Free consultation · no credit card needed
Quite literally life saving. Having been living with depression for 22 years, I never knew life could be this … well, joyous!!
E
Eva DJoyous patient, US
Your dose is found, not guessed.
Treatment starts low and rises in small steps only as tolerated, until your clinician finds your lowest effective dose. There is no standard dose: yours is set from your own daily check-ins, and every dose change is approved by a licensed clinician.
Start on a low doseCheck in dailyYour optimal dose is found & adjusted over time
Under a cloud?
Ketamine works differently.
Glutamate, not serotonin. A different system than antidepressants.
“I don’t feel like a cloud is constantly over me.” Jade Echo, Joyous patient
86%
cut their depression score in half or better (PHQ-9, six weeks, n = 43,563)
54%
reached the remission range for depression (PHQ-9 under 5, six weeks)
Not easy cases. Most Joyous patients had lived with their symptoms for over two years, and about 29% had tried three or more antidepressants.
* Joyous outcomes data · 66,727 patients · moderate-or-worse at start · self-reported PHQ-9 · individual results vary
Study detailsPatients who started with moderate-or-worse symptoms, self-reported PHQ-9 scores at six weeks. In STAR*D, the largest trial of SSRIs, 47% of patients responded and 28% reached remission on their first antidepressant. Different studies and populations, not head-to-head trials (Trivedi et al., Am J Psychiatry 2006).
Why people choose Joyous
Come for joy.
Most people don’t come to feel less bad. They come to feel good.
Relief that starts in week one
In Joyous outcomes data, depression scores dropped 38% on average by the end of week one, well before the 4 to 8 weeks antidepressants are generally described as taking.
See how the free consultation works ↓
“I have truly never felt better than the few months I was in treatment with Joyous.”
Heidi
Depression score, PHQ-9 (lower is better). Illustration of milestones, not a measured curve.
↻ ReplayQuestions people actually ask
Got a question we didn’t cover? Email [email protected] or text +1 (844) 774-0909.
Does ketamine work for depression?
Yes, in Joyous outcomes data: 86% of patients who started with moderate or worse depression (PHQ-9 of 10 or more) cut their score in half or better within six weeks, and 54% finished in the range clinicians call remission. Patients who started with moderate-or-worse symptoms · six weeks · self-reported PHQ-9/GAD-7 scores · individual results vary.
Does ketamine therapy get you high?
No. The Joyous dose is designed not to: you stay coherent and aware throughout. Most people describe it as calming rather than intoxicating.
Is at home ketamine safe?
At-home ketamine treatment rests on three things: a low daily dose designed not to produce a high, screening by a licensed clinician before you start, and daily check-ins so the dose only moves when your clinician approves it. You stay coherent and aware throughout; the most common side effect in Joyous outcomes data was drowsiness (about 1 in 4 patients in week one, fewer than 1 in 5 by week six). Do not drive for 1 to 2 hours after a dose.
Who is ketamine therapy not right for?
Psychosis or bipolar I, active suicidal intent, uncontrolled high blood pressure, seizure history, a history of stroke or brain injury, pregnancy or breastfeeding, active or past substance use disorder. A licensed clinician screens out patients with any of these.
Can I keep taking other medications?
Many patients continue their existing antidepressant during treatment. Your clinician reviews your current medications at your video assessment and decides what is compatible. Bring your medication list.
How is this different from Spravato or IV ketamine?
Spravato is esketamine, a nasal spray FDA-approved for treatment-resistant depression, taken under observation at a certified clinic. Clinic infusions are higher doses, also given under observation. Joyous prescribes racemic ketamine off-label as a low daily dose you take at home, adjusted from your own check-ins. The point of the low dose is that no one needs to sit with you while you take it, paired with proper mental-health follow-up.
How fast does ketamine therapy work?
Antidepressants are generally described as taking four to eight weeks to work. In the Joyous cohort the average depression score had dropped 38% by the end of week one, and the typical patient’s score was cut in half within about 16 days. That is a median; reaching the remission range took a median of 48 days.
What does low-dose ketamine feel like?
Our low-dose protocol is designed to keep you fully present and coherent during treatment. After about 15 minutes you may notice a subtle calm and possibly some lightheadedness that quickly dissipates. Over the first weeks your dose is adjusted from your daily check-ins, so if the feeling isn’t right it will get adjusted.
Is ketamine legal?
Yes. Ketamine is a federally controlled prescription medication: legal when prescribed by a licensed clinician, and prescribed off-label for depression, anxiety and PTSD. Joyous clinicians prescribe it in 32 states.
Do I need to be in therapy to do this?
No, but many people are. 38% of Joyous patients were in talk therapy at the same time, rising to 44% among those with moderate or worse symptoms. If therapy is out of reach, the Joyous patient app includes curated treatment courses and resources you can work through on your own.
How much does ketamine therapy cost?
Joyous costs $129 a month on the plan with a three-month commitment, or $159 a month with no commitment, which drops to $129 after three months. Both include the medication.
Does insurance cover ketamine therapy?
Insurance does not cover Joyous. HSA and FSA funds are accepted.
How it works
Treatment starts low and rises in small steps only as tolerated, until your clinician finds your lowest effective dose. You check in daily, and the dose only moves when your clinician approves it.
Who it’s for
Most patients come for depression, anxiety and PTSD; many also with chronic stress and burnout, high-functioning anxiety or depression, grief and trauma, OCD, and chronic pain. Most had lived with their symptoms for over two years. About 17% had never taken an antidepressant; about 29% had tried three or more.
Who is screened out
Psychosis or bipolar I, active suicidal intent, uncontrolled high blood pressure, seizure history, a history of stroke or brain injury, pregnancy or breastfeeding, active or past substance use disorder. A licensed clinician screens out patients with any of these.
Join 120,000+ patients treated by Joyous
Talk to a clinician first.
Pay nothing today.
- 1
Free video consultation Free
Meet the Joyous medical team. No credit card, no commitment. - 2Decide togetherA licensed provider goes over your history and questions, and you decide together if ketamine is right for you.
- 3Only then, pick a planIf it is, choose a plan and pay for your first month. Cancel anytime.
Your free consultation$0
- ✓Video visit with the Joyous medical team
- ✓Your medical history and questions reviewed
- ✓No credit card needed
- ✓No commitment
No credit card needed. If it’s not right for you, you just walk away.
If you’re approved: pick a plan
Best price
3-month plan
$129/mo
with a 3-month commitment
No commitment
Month to month
$159/mo
then $129/mo after 3 months
Every plan includes
- Medication & shipping
- Provider appointments
- Be Joyous™ patient platform
- Joyous Care support
- Mental health resources
- Access to our patient community
HSA/FSA accepted · Not covered by insurance
S
“Least expensive option for low dose oral ketamine. Everything is done online over zoom and its very easy.”
Stephen C., Trustpilot
Led by clinicians
Directed by licensed clinicians, the Joyous protocol is continuously adapted to each patient via a system of daily check-ins.
Medically reviewed by Bobbi Leben, MD.
Bobbi Leben, MD
Chief Medical Officer, Joyous. Double board certified.
There is no health without mental health.
The Joyous team
A Public Benefit Corporation
Most people don’t come to feel less bad. They come to feel good.
Come for joy.
65% of patients come for positivity and joy (n = 28,013)
66,727 patients in Joyous outcomes data
Come for joy
120,000+ patients treated
4.7 on Trustpilot
LegitScript certifiedPublic Benefit Corporation
Available in 32 states
HSA/FSA accepted
★ 4.7 on Trustpilot · 2,246 reviews
Real people, real words
The best treatment for depression and anxiety!
I started to feel major improvements in my depression within a couple of weeks. After about 2 months, I felt a tremendous relief in my anxiety symptoms!
Anjanette
My depression went away
My journey was great. I took it for 5 months. Now my anxiety is almost completely gone. Also my depression went away. I feel a whole lot better than I have in ten years
Brandon G
This treatment has saved my life
I’ve had treatment resistant depression my entire life. Really, my entire life. To say I’ve tried everything is an understatement. Diet changes, therapy, antidepressants- you name it, I’ve tried it.
Jade Echo
One of the best decisions I’ve ever made
I’ve been on SSRIs, SNRIs & benzodiazapines since childhood. Nothing has ever worked without awful side effects. Joyous has been like magic for my brain. I’m actually making progress in therapy!
Amber M.
It improved my depression significantly
It took some time before the Ketamine started to work. Maybe two or three months. But I can honestly say it improved my depression significantly!
Deb C.
It helped me get over the depression hump
I was on ketamine 14 months. It has helped me get over the depression hump I was experiencing. It helped clear my mind from intrusive thoughts and feelings. It helped me sleep.
Polly H.
Grateful for Joyous helped me through Depression and Anxiety
I was struggling with grief and depression, and traditional SSRIs left me feeling tired, unlike myself, or came with difficult side effects. Ketamine has been a different experience no side effects, and a noticeable lift in my mood and clarity.
Shelly V.
Joyous Transformed my life
Amazing and life changing support. I have truly never felt better than the few months I was in treatment with Joyous. I recommend them to anyone who is struggling with mental health.
Heidi
Start with a free consultation
Free consultation · no credit card needed
Four kinds of ketamine therapy
Ketamine therapy comes in four main forms. Here is how they differ.
IV infusion
Spravato
Higher-dose at home
Taken at home
You stay coherent and aware
No one needs to sit with you
Sitter often required
Dosing
Small daily dose
Series of sessions
With an oral antidepressant
Set weekly sessions
Adjusted from daily check-ins
FDA status for mental health
Off-label
Off-label
FDA-approved
Off-label
Source: joyous.team/ketamine-therapy, “What kinds of ketamine therapy are there?”
Explore my options
Free consultation · no credit card needed
About Joyous
To enable individuals, families, communities, and humanity to live a Joyous life.
Joyous is a Public Benefit Corporation that puts patients’ well-being as our #1 priority, born out of a collaboration among medical experts, psychology specialists, and Silicon Valley technologists.
Conditions we treat
Joyous clinicians can prescribe ketamine for any psychiatric diagnosis where they judge it appropriate.
Most commonDepressionLearn more
Most commonAnxietyLearn more
Most commonPTSDLearn more
Chronic stressLearn more
Performance anxietyLearn more
GriefLearn more
OCDLearn more
SleepLearn more
Joyous at-home ketamineFree consultation · no card needed
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